The current research was conducted with the aim of philosophical-psychological explanation of the relationship between the soul and the body based on Islamic thought, emphasizing the view of Allameh Tabatabai. The findings were analyzed using qualitative content analysis (descriptive-analytical). Investigations have shown that Allameh Tabataba'i has made the philosophical foundations the main support of discussions in Quranic debates, and in some cases he has distanced himself from the method of interpreting the Quran to the Quran. Allameh Tabatabai, following the transcendental wisdom, believes that the relationship between the soul and the body is intrinsic and real from the point of view of Allameh Tabatabai, in such a way that they can never be separated from each other. The soul and the body with all the nervous and hormonal structure are two essences of different nature. The soul is immaterial and the body is physical and has material interactions. The reality of a person is his ego, and the body is a tool for the ego. Interactions in the realm of human existence are sensual activities, and the activities of the body as tools and underlying causes are associated with the activities of the soul, not that there is an independent thing called the activity of the body. In the psychological analysis of the relationship between the soul and the body, many cases of the effects of the soul on the body and the body on the soul were mentioned. Correct understanding in this category helps to find causes in behavioral phenomena and control them. The correct interpretation and analysis of the relationship between the soul and the body and the examination of different theories can be the basis for establishing scientific principles in this field.